This core will be developed to address the complex issue of health effects of chemicals/particles and their mixtures (including environmentally relevant discharges) on wildlife (and human) health. The core will include work studying ED in wildlife populations. Understanding the possible impacts of EDCs (and other pollutants) on wild populations will require the development of associated knowledge on the basic biology of sentinel organisms. This core will also consider (where possible) chronic exposure work to pollutants of concern.