There is strong support in the UK-Japan Research Partnership for using risk assessment (combining exposure and hazard assessment) as the best approach for managing chemicals, utilising the knowledge gained in the other Core Projects and the OECD framework for endocrine disrupter assessment.  Supporting the integration of intelligent testing strategies using a mode-of-action approach together with population-relevant endpoints is also a key priority (linking Core Projects 2 and 3), for both single chemicals and complex mixtures. Policy trends indicate that another area for prioritization over the next five years includes understanding exposures and impacts of endocrine disrupters and related emerging chemicals in sediments and sediment dwelling organisms (both freshwater and marine) to support national and international policy needs. One option for the future is to approach this need through selected chemical case studies which connect all four Core Projects.